Let's talk Peptides

It was great!!!

First let's ask ourselves exactly what is HGH??
Growth hormone (GH) is a peptide hormone. It stimulates growth and cell reproduction in humans and other animals.
What does HGH it do??

GH stimulates production of insulin -like growth factor 1 (IGF-1) in the liver.  Which is the principal site of IGF-1 production. IGF-1 has growth-stimulating effects on a wide variety of tissues. Additional IGF-1 is generated within target tissues, making it apparently both an endocrine and an autocrine/paracrine hormone.  This is the factor which stimulates muscle growth


Now what is IGF-1??

Insulin-like growth factor 1 (IGF-1), is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults.

What does IGF-1 do??

IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

Almost every cell in the human body is affected by IGF-1, especially cells in muscle, cartilage, bone, liver, kidney, nerves, skin, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis.

IGF-1 has fat burning properties because IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use , it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don't actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and steroid usage you are able to mature these new cells, in other words make them grow and become stronger. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.


Whats the difference?

Insulin-like Growth Factor-I LR3 (IGF-I LR3) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R³), and a 13 amino acid extension peptide at the N-terminus.

How is it better?

IGF-I LR3 has been developed specifically for supplementation of mammalian cell culture to support the survival and proliferation of cells. It is engineered to have a higher biological potency than native IGF-I or IGF-II and has several advantages over recombinant insulin, potency being among them. Published research has shown that supplementation of cell cultures with IGF-I LR3 at a much lower concentration results in equivalent or better productivity than supplementation with standard concentrations of insulin. IGF-I LR3 is better able to stimulate the Type I IGF receptor and thus induce a higher level of activation of intracellular signaling molecules which are responsible for promoting cell survival by inhibition of apoptosis. And the best part, its cheaper giving you more bang for your buck.